Cartherics and TiCARos collaborate to lead advancement of CLIP-CAR technology

Cartherics and TiCARos have recently formed a collaboration to develop CLIP-CAR constructs for assessing the function of NK cells. This partnership aims to enhance the efficacy of cancer therapies by combining TiCARos’ CLIP-CAR technology with Cartherics’ allogeneic NK cell platform.

TiCARos is a company that specializes in developing CAR-T cell products for treating solid and blood cancers using its unique CLIP-CAR approach. This approach modifies the CAR structure to improve the immune synapse between immune cells and target tumor cells, resulting in improved efficacy in models.

Cartherics’ CEO, Professor Alan Trounson, believes that collaborating with innovative companies like TiCARos will help build a leading portfolio of therapeutic products for cancer treatment. The collaboration between the two companies aims to develop a CAR-NK product targeting tissue factor (TF) for triple negative breast cancer and other challenging cancers. Each company has nominated a specific tumor antigen to target with their CARs, with Cartherics focusing on TF and TiCARos targeting CD19.

This partnership aims to accelerate pipeline programs and expand the use of TiCARos’ technology beyond autologous cell therapies. If the research collaboration yields positive results, Cartherics and TiCARos will negotiate a development and commercialization agreement for their CAR-NK therapeutic approach.

The collaboration between these two companies represents an exciting opportunity to advance cancer treatments through innovative technologies that enhance immune synapses between immune cells and tumor cells. With this collaboration, we can expect significant progress towards developing effective CAR-NK therapies that target challenging cancers like triple negative breast cancer.

By Aiden Johnson

As a content writer at, I have a passion for crafting engaging and informative articles that captivate readers. With a keen eye for detail and a knack for storytelling, I strive to deliver content that not only informs but also entertains. My goal is to create compelling narratives that resonate with our audience and keep them coming back for more. Whether I'm delving into the latest news topics or exploring in-depth features, I am dedicated to producing high-quality content that informs, inspires, and sparks curiosity.

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